Prof. Stephen Tait investigates mitochondrial regulation of cell death and inflammation in the context of cancer.
His lab is based at the Cancer Research UK Scotland Institute in Glasgow, UK. His lab’s major contributions include:
1) the discovery that sub-lethal engagement of mitochondrial apoptotic signaling can be oncogenic
2) killing cancer cells under caspase inhibited conditions engages anti-tumor immunity
3) discovery that mitochondria trigger various inflammatory pathways during cell death
4) mitochondrial permeabilisation directly connects cell death and senescence
His lab is supported by funding from Cancer Research UK, BBSRC and Prostate Cancer UK.