Luc Buée, CNRS Research Professor, is Director of the Lille Neuroscience & Cognition Research Centre and Head of the Inserm laboratory «Alzheimer & Tauopathies» at the University of Lille, France. Located on the Lille hospital campus, his laboratory belongs to the Lille Centre of Excellence in Neurodegenerative disorders (LiCEND) and is also part of the LabEx DISTALZ (National consortium on Alzheimer’s disease).
Luc Buée has been working on Alzheimer’s disease and related disorders for more than thirty years (>300 articles in Pubmed). He began his work on the role of proteoglycans in Alzheimer’s disease during his doctoral training at Mount Sinai Medical Center, New York. He made some of the pioneering neuropathological observations on microvasculature abnormalities in neurodegenerative disorders. He was involved in the initial biochemical characterisation of tau aggregates in certain neurodegenerative disorders (barcode tauopathies). He then developed experimental models to better understand the role of post-translational modifications in tau aggregation and secretion. These experimental models are now widely used to evaluate therapeutic strategies for tauopathies (immunotherapy, intrabodies, small molecules, non-drug therapy…). With his team, he has also discovered numerous non-microtubular functions of the tau protein. He is currently working on the pathophysiological consequences of neurofibrillary degeneration and their links with amyloid pathology and inflammation in Alzheimer’s disease.
Luc Buée is also involved in different scientific advisory boards, scientific programmes and operating committees. He is a foreign member of the Royal Academy of Medicine of Belgium and the organiser of the Eurotau meetings. Moreover, he has received different awards.